When melanoma cancer cells are forced through channels narrower than 10 micrometres, they begin to behave more like stem cells, gaining traits that could help them survive, spread, and form new tumours | AI News Digest
Researchers at UNSW Sydney have discovered that when melanoma cancer cells are forced through channels narrower than 10 micrometres, they begin to exhibit stem cell-like traits, enhancing their ability to survive and form new tumours. This finding, published in Nature Communications, suggests that the mechanical pressure from narrow blood vessels may trigger cancer cells to become more aggressive. The study utilized a microfluidic device to simulate blood flow, revealing that squeezed cells developed significantly more tumours in mice. This research could pave the way for new strategies to prevent cancer metastasis by targeting the mechanical forces involved. The insights gained may also help in assessing the risk of metastasis in patients and developing innovative treatment options.
